In ascites, the Cyr61 level of ovarian serous cystadenocarcinoma (n = 66) and serous cystadenoma (n = 18) was 1624.33 ± 191.92 cf. 230.11 ± 25.63 pg/ml respectively (p < 0.001); in serum, the Cyr61 level was 77.21 ± 4.81 cf. 13.32 ± 3.14 pg/ml, correspondingly (p < 0.001). Here, CCN1 is linked to serous cystadenoma.