In order to determine if KC presence and/or type of treatment(s) affected the levels of either LH or FSH, we investigated the following groups: Individuals with: (1) KC on one eye, (2) KC on both eyes, (3) KCs with corneal transplants, (4) All KCs independent of treatment(s), (5) KCs with collagen crosslinking on one eye, (6) KCs with collagen crosslinking on both eyes, and (7) All KCs with collagen crosslinking treament, independent of the number of eyes. Here, PLOD1 is linked to keratoconus.