Baritaki et al. reported that treatment of tumour cells with various chemotherapeutic drugs not only inhibits NF-κB activity but also sensitizes the cells to TRAIL-induced apoptosis concurrently with upregulation of death receptor 5 (DR5) expression and inhibition of the transcription repressor Yin Yang 1 (YY1) [77]. The gene discussed is TNFSF10; the disease is neoplasm.