Frankenberger et al. demonstrated that RKIP expression in metastatic triple-negative breast tumours markedly reduces the number and metastatic potential of infiltrating TAMs, which by itself translated into a decrease in tumour cell invasiveness and secretion of pro-metastatic factors, namely progranulin (PRGN) and tumour necrosis factor receptor 2 (TNFR2). This evidence concerns the gene PEBP1 and neoplasm.