TNFSF10 and neoplasm: In fact, some agents have already been reported as able to induct RKIP expression, resulting in the reversal of resistance and sensitization to TNF-related apoptosis-inducing ligand (TRAIL) and Fas ligand (Fas-L)-mediated apoptosis, two important mechanisms for tumour cells death by the immune system [47,48,77,78,79].