In contrast, upon TDP-43 depletion in human neuroblastoma M17 cells, overall SORT1 mRNA levels significantly increased 1.4 fold, as we previously described [20], mainly due to an increase of the main SORT1Δex17b isoform (Figure 5b) as the SORT1ex17b isoform represents a rare splicing isoform in human cells [21]. The gene discussed is SORT1; the disease is neuroblastoma.