Upon Tdp-43 knock-down in murine neuroblastoma N2a cells, a significant increase of both intracellular (2.1-fold) and secreted (1.6-fold) Pgrn protein levels were observed, although Grn mRNA levels remained unchanged (Supplementary Figure S1), confirming the results obtained in NSC-34 cells. This evidence concerns the gene TARDBP and neuroblastoma.