In murine motoneuronal-like NSC-34 cells, we confirmed that TDP-43 depletion induces Sort1 splicing changes with an upregulation of the longer Sort1ex17b isoform as already described in adult mouse brain and in murine neuroblastoma N2a cells [6,21,38], but without changes of total intracellular Sort1 protein levels, thus suggesting that progranulin uptake via sortilin is not affected by TDP-43 knock-down in mice. This evidence concerns the gene TARDBP and neuroblastoma.