In murine NSC-34 cells, we observed that TDP-43 gene silencing induced a significant 1.8-fold increase of the Sort1ex17b isoform with unchanged overall expression of the Sort1 gene (Figure 5a), similarly to what we observed in another murine neuronal-like cell model, the neuroblastoma N2A cells (Supplementary Figure S3), and confirming previous literature data [6,21]. Here, SORT1 is linked to neuroblastoma.