BCL2 and neoplasm: Yang et al. indicated that the upregulation of miR-195 with mimic oligonucleotides in MCF-7/ADR cells (an Adriamycin-resistant MCF-7 subline) increased the sensitivity of breast cancer to Adriamycin treatment, reduced the tumor cell survival and promoted tumor cell apoptosis through inhibition of Raf-1, Bcl-2, and P-glycoprotein expression [222].