KLK3 and posterior cortical atrophy: Taken together, our results demonstrate that (1) GOAT plays an oncogenic role in PCa, (2) urine GOAT levels are directly associated to key clinical parameters of aggressiveness, and (3) urine GOAT levels outperform, at least in the grey zone, the capacity of plasma PSA to distinguish between SigPCa/PCa patients and non-PCa patients.