Moreover, we have recently demonstrated in a cohort of 312 patients that plasma GOAT levels are higher in patients with PCa and particularly, in patients with clinically significant PCa (SigPCa, defined as PCa with Gleason score ≥ 7) as compared to controls, which included patients with suspected PCa but negative biopsy results and those with indolent PCa (defined as PCa with Gleason 6) [13]. This evidence concerns the gene MBOAT4 and posterior cortical atrophy.