Paradoxically, it has been reported that G-MSCs in vitro are not capable of generating Tregs; however, after their application in an acute GVHD model, high levels of Foxp3 expression were detected, along with a reduction in the levels of proinflammatory cytokines IL-17 and IFNγ and an increase in IL-2 levels, the role of which is important for the differentiation of induced regulatory T-cells (iTregs), supporting the suppressor function of CD4 iTregs under inflammatory conditions [64]. This evidence concerns the gene CD4 and graft versus host disease.