ATG7 and Parkinson disease: Indeed, knockout of the Atg7 gene in mice, an essential gene for autophagy, shows in vivo typical Parkinson’ disease (PD) features like Lewy bodies (LBs) formation, including endogenous synuclein and neuronal loss, as well as hepatomegaly with mutant hepatocytes showing accumulation of ubiquitin-positive aggregates [91,92].