In particular, OleA prevents amylin aggregation into amyloid fibrils, whose pancreatic presence is considered one of the causes of the sufferance and functional impairment of insulin-secreting cells in T2DM (see 5: Oleuropein as anti–amiloid mean) [74] Therefore, many studies conducted in animal and cell models have reported that Ole has the property of decreasing blood glucose and cholesterol levels, and improving oral glucose tolerance and insulin sensitivity [41,75,76]. The gene discussed is INS; the disease is type 2 diabetes mellitus.