INS and Insulin resistance: Interestingly, in the context of these latter metabolic disorders, both characterized by insulin-resistance, de BocK et al. [78] showed a recovery of insulin sensitivity and pancreatic β-cell secretion capacity, in a group of overweight middle-aged men that received capsules of oleuropein-leaf extracts for 12 weeks, corroborating previous findings on the hypoglycemic effect of oleuropein [41,71,80].