In the present study, therefore, we examined whether adeno-associated virus serotype 1-constitutively active Ras homolog enriched in brain [AAV1-Rheb(S16H)] administration induces beneficial effects in 5XFAD mouse model, a mouse model of amyloid deposition that expresses five familial AD (FAD) mutations and recapitulates major features of AD [21]. The gene discussed is RHEB; the disease is Alzheimer disease.