Given the effect of the DRD2/ANKK1 TaqIA polymorphism on dietary intakes and metabolic status, the detection of this genotype along with other nutrient-sense genes could be an auxiliary tool for the identification of high-risk groups, as well as for a precise nutrition management of hypertriglyceridemia in T2D and the prediction of resistance or responsiveness to dietary interventions. The gene discussed is DRD2; the disease is hypertriglyceridemia.