Italiani et al. [29] conducted a study on IL-1 family molecules and SLE, and reported that IL-33 was significantly lower in SLE (p = 0.002), whereas soluble interleukin 1 receptor 4 (sIL-1R4), its natural inhibitor, was significantly higher (p < 0.0001). The gene discussed is IL1B; the disease is systemic lupus erythematosus.