SRSF2 mutations seem to induce differential splicing in EZH2, a known gene implicated in the pathogenesis of MDS and AML, and in several HNRNP proteins, including HNRNPA2B1, HNRNPH1, HNRNPM, and HNRNPH3 [36,37]. The gene discussed is SRSF2; the disease is acute myeloid leukemia.