Mutations in SF3B1, SRSF2, and U2AF1 have been associated with specific disease subtypes with SF3B1 being mostly mutated in MDS-RS, SRSF2 occurring mostly in chronic myelomonocytic leukemia (CMML), and U2AF1 in secondary AML [9]. This evidence concerns the gene SRSF2 and myelodysplastic syndrome.