In MDS, SF mutations are associated with mutations in epigenetic genes, e.g., SF3B1 with DNMT3A mutations, SRSF2 with RUNX1, IDH1/2 and ASXL1 mutations and U2AF1 with ASXL1 and DNMT3A mutations. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.