SF3B1 and myelodysplastic syndrome: Recently, luspatercept (ACE-536), a fusion protein containing a modified extracellular domain of the human activin receptor type IIB combined with a human IgG1 Fc domain and influencing the TGF-β and SMAD family proteins, is a phase II clinical trial for MDS patients and seems to induce a better clinical response in patients with SF3B1 mutations [55].