Mutations in SF3B1, SRSF2, and U2AF1 have been associated with specific disease subtypes with SF3B1 being mostly mutated in MDS-RS, SRSF2 occurring mostly in chronic myelomonocytic leukemia (CMML), and U2AF1 in secondary AML [9]. Here, SF3B1 is linked to acute myeloid leukemia.