We demonstrated preliminarily that meningitic E. coli induced the expression of ANGPTL4 through the activation of PPARβ/δ signaling pathway, and ANGPTL4 contributed to the infection-mediated BBB disruption via the ARHGAP5/RhoA/MYL5 signaling cascade, affecting the actin cytoskeleton. The gene discussed is RHOA; the disease is infection.