ARHGAP5 and escherichia coli infection: Taking all these clues together, we therefore present our hypothesis and have evidenced that meningitic E. coli infection of hBMECs triggered ANGPTL4-mediated ARHGAP5/RhoA signaling, which increased MYL5 expression and finally led to the dysfunction of BBB, and this ANGPTL4–ARHGAP5–RhoA–MYL5 may present another way for meningitic E. coli penetration of the BBB.