Lytic HCMV infection leads to a dysregulated cell cycle, and the IE gene products interfere with key cellular factors, including retinoblastoma protein family (Rb), cyclins, p53, Wnt, phosphatidylinositol 3-kinase/Akt, human telomerase reverse transcriptase (hTERT), and NF-κB to increase the immortal properties of infected cells [11]. Here, NFKB1 is linked to cytomegalovirus infection.