Kotamraju et al. showed that simvastatin and fluvastatin induce apoptosis in breast cancer cells through production of NO mediated by iNOS so that exposure of MCF-7 breast cancer cells to sepiapterin, an eNOS activator, increases NO synthesis and improves the pro-apoptotic effects of simvastatin and fluvastatin [106]. This evidence concerns the gene NOS2 and breast carcinoma.