Recently, it was also confirmed in mice that injections of antisense-oligonucleotides against ataxin-2 into the cerebrospinal fluid (CSF) of SCA2 and ALS mouse models were able to prevent the neurodegenerative process, with an extension of lifespan up to >10 fold in some animals [33,34]. This evidence concerns the gene ATXN2 and spinocerebellar ataxia type 2.