ATXN2 and obesity due to melanocortin 4 receptor deficiency: The genetic deletion of ataxin-2 orthologs rescues the lethality of poly(A)-binding-protein-KO in yeast [47], triggers phenotypes of large cell size and fat accumulation in nematodes [48], produces female sterility in flies [49], and results in obesity, insulin resistance, hyperlipidemia, and infertility in mice [50].