ATXN2 and multiple system atrophy: It is also relevant to know that SCA2 has an identical pattern of neurodegeneration as multiple system atrophy (MSA) [56,96] where progressive aggregation of alpha-synuclein oligomers in oligodendrocytes acts as a causal trigger of pathogenesis and usually leads to either cerebellar or Parkinsonian manifestation [97] just like SCA2 [98].