CERS1 and myoclonic epilepsy: It is interesting to note that Cers2 is mainly expressed in myelinating oligodendrocytes and responsible for the production of very long-chain C26 ceramides [111]; thus, its dysfunction leads to myoclonic epilepsy due to the myelin instability from C24–26 deficiency [112]; in comparison, Cers1 metabolizes C18 ceramides; its mutation also leads to myoclonic epilepsy [113], but Cers1 is also critical for cerebellar Purkinje neurons [114].