ORAI1 and atherosclerosis: Importantly, ORAI1 expression was increased in atherosclerotic plaques of ApoE−/− mice, and moreover, knockdown of Orai1 for 4 weeks in the cholesterol-fed ApoE−/− mice attenuated atherosclerosis progression by preventing apoptosis of lesional macrophages, by decreasing the expression of inflammatory genes in the atherosclerotic lesions, and by attenuating recruitment of myeloid cells into the atherosclerotic plaques [109].