On the other hand, epigenome-wide association studies (EWAS) in MCTD patients [33] and Genome-wide transcriptional profiling in SLE or SSc patients [24,34,35] confirmed the overexpression of IFN-inducible genes, known as the “interferon (IFN) signature” in these patients. Here, IFNA1 is linked to systemic lupus erythematosus.