Autoantibodies against RNA-associated proteins, such as anti-U1-RNP, Anti-Sjögren’s-syndrome-related antigen A (anti-SSA; anti-Ro60; and, anti-Ro52), and anti-Sjögren’s syndrome type B (anti-SSBalso known asanti-La) can enhance the immune response. The gene discussed is TRIM21; the disease is Down syndrome.