MCU and mesothelioma: They also found a reduced level of the Mitochondrial Calcium Uniporter (MCU), highlighting that the alteration of mitochondrial Ca2+ uptake is crucial for the unresponsiveness of mesothelioma cells to apoptotic stimuli, and silencing MCU by RNAi or NaV (sodium orthovanadate) treatment to restore the Ca2+ homeostasis and mesothelioma sensitivity to apoptotic stimuli [29,30,34,40,41,42,43,44,45,46,47,48,58].