NFKB1 and obesity due to melanocortin 4 receptor deficiency: To gain further molecular insight into the anti-inflammatory activity of OC and OA, we studied the effect of these polyphenols on the activation of NF-κB, which transcriptionally regulates a plethora of pro-inflammatory genes including those here assessed, and functions as a link between inflammation and dysmetabolism in obesity [6,101].