Although metabolic consequences of manipulating VEGF expression in mice are not consistent in the literature, a recent study has found that adipose-specific VEGF repression in mice leads to white AT browning, uncoupling protein(UCP)-1 upregulation accompanied by reduced lipid accumulation in AT, resistance to obesity, and increased insulin sensitivity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.