NF1 and breast carcinoma: In addition to these four genotype–phenotype correlations, the findings of recent studies suggest that the type and the position of NF1 mutations may be the main determinant of the risk of developing spinal neurofibromas (patients more likely to have MS or SS mutations) [57], pulmonary stenosis (a significantly higher prevalence of non-truncating NF1 mutations) [58], breast cancers (a higher proportion of both nonsense and missense mutations) [12], and OPGs.