LOXL1 and heart disorder: Nonsynonymous coding single-nucleotide polymorphisms (SNPs) in the LOXL1 gene are the major known genetic risk factor for pseudoexfoliation syndrome (XFS; OMIM#177650) [38], an aging-related systemic disease involving an abnormal ECM deposition, characterized by an increased risk of glaucoma, and a high susceptibility to heart disease among others [39].