Only one gene passed all the evaluations: NTF3. This gene is underexpressed in HNSCC tumor tissue versus normal adjacent tissue, it is targeted by miR-21-5p, according to the TargetScan online tool, its low expression in tumor tissue reduces the overall survival rate of HNSCC patients, and it has a negative correlation with miR-21 expression. The gene discussed is NTF3; the disease is head and neck squamous cell carcinoma.