MTREX and leukemia: As demonstrated in Figure S13a, amplification and deep deletion usually happened in SUGP1, DHX16, FUS, HNPNPR, DHX15, and NAA38. Meanwhile, the following genes mainly have deep deletion and missense mutation: FUS, DHX15, PLRG1, and MTREX. Moreover, the alterations of eight hub genes ranged from 0.5% to 1.5% in 13 leukemia tissues [11] (Figure S13b).