Therefore, the current research on the pathogenesis of T-ALL mainly includes the following components: PI3K-AKT-mTOR, IL7R, BRD4/MYC, NOTCH1, BCL2, Cyclin D3 (CDK4/CDK6), SINE, and rationale combinations of above approaches [3]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.