As a pro-oxidant, uric acid can decrease the production and bioavailability of nitric oxide, activate NACHT, LRR and PYD domains-containing protein 3 inflammasome, and produce interleukin (IL)-1β, leading to activation of the renin−angiotensin system and endothelial dysfunction [2,9,19]. Here, HSPB3 is linked to endothelial dysfunction.