Genistein downregulated DNMT1, DNMT3B, DOT1L, UBE2A, AURKA, KDM1A, AURKB, KDM6B, HDAC5, HDAC1, SETD1B, SUV420H1, SUV39H1, HDAC6, DNMT3A, KDM5C and PAK1. Genistein also upregulated several chromatin modifiers including SETD5, SETD7, SETD6, CIITA and ESCO2. These genes could contribute to the anti-proliferative, anti-metastatic and anti-cancer activity of genistein. This evidence concerns the gene HDAC6 and cancer.