TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: In accordance with our results, a previous study showed that the treatment of AML cell lines, CML-T1 and HL-60, with a combination of SAHA and DAC upregulated the cleavage of procaspase 3 and 7 and induced the p53-dependent apoptotic way of cell death in CML-T1 [46].