The second reported that anti-ApoA-1 IgG levels were inversely associated with PD- and positively associated with ABCA1-CEC in healthy obese subjects, with the capacity, to enhance ABCA1-CEC in vitro while repressing PD-CEC, leading to foam cell formation [19], the hallmark of atherosclerosis [20]. The gene discussed is ABCA1; the disease is atherosclerosis.