Among these, 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) and low-density lipoprotein receptor (LDL-R) are known as key cholesterol homeostasis regulatory elements leading to the developments of statins, the most efficient and commonly used pharmacological molecules available to prevent atherosclerosis-related complications [21]. The gene discussed is LDLR; the disease is atherosclerosis.