Association of fetuin-A with atherosclerotic disease has thus been the subject of many investigations; patients suffering from symptomatic CVD exhibited increasing concentrations of Fet-A in coronary artery disease (CAD), in opposition to peripheral artery disease (PAD); moreover, Fet-A appeared to correlate positively with fatty liver disease in CAD, in contrast to PAD, thereby supporting the hypothesis that Fet-A might play distinct roles during atherosclerosis depending on the affected artery arterial [108]. The gene discussed is AHSG; the disease is fatty liver disease.