As some IAP family members were reported to be transcriptional targets of Yorkie, YAP drosophila ortholog [13], the activity of which is increased and deregulated in RASSF1A-depleted NSCLC cells [4], this study hypothesized that IAPs could underlie the predictive value of RASSF1A promoter methylation. This evidence concerns the gene RASSF1 and non-small cell lung carcinoma.