The authors were intrigued to further understand how the RASSF1A expression loss could predict either the effectiveness of pre-operative taxol-based therapy or the failure of pre-operative gemcitabine treatment in patients with early-stage NSCLC from the Phase 3 IFCT-0002 trial, as reported in detail in our previous work [3]. The gene discussed is RASSF1; the disease is non-small cell lung carcinoma.