TP53 and B-cell chronic lymphocytic leukemia: Next generation sequencing (NGS) identified a number of mutations in genes related to regulation of key cellular processes, e.g., response to DNA damage and cell cycle control (ATM, TP53, RB1, BIRC3), RNA processing (SF3B1), Notch signaling (NOTCH1, NOTCH2, FBXW7) and cytokine signaling (NRAS, KRAS, BRAF, MYD88, DDX3X, MAPK1) that modify CLL’s clinical course [5,6,7,8,9].