Next generation sequencing (NGS) identified a number of mutations in genes related to regulation of key cellular processes, e.g., response to DNA damage and cell cycle control (ATM, TP53, RB1, BIRC3), RNA processing (SF3B1), Notch signaling (NOTCH1, NOTCH2, FBXW7) and cytokine signaling (NRAS, KRAS, BRAF, MYD88, DDX3X, MAPK1) that modify CLL’s clinical course [5,6,7,8,9]. Here, ATM is linked to B-cell chronic lymphocytic leukemia.