TNF and neoplasm: Activating mutations in oncogenic RAS/BRAF/MEK pathways trigger a tumor-intrinsic inflammatory network with the concerted regulation of master transcription factors (TFs) including STAT3 [2], NF-κB and AP-1 [3,4] which in turn trigger the expression of cytokines, including IL-6, IL-1, IL-10, TNF and VEGF [5].