In conclusion, these studies strengthen the interest of regulating STAT3/STAT5 activities in CD8 T cells to improve adoptive cell therapy: given their tightly balanced contribution to T cell memory fates, increased STAT3 or STAT5 activity is expected to improve the therapeutic success of hematological and non-hematological cancers, respectively. The gene discussed is STAT3; the disease is hematopoietic and lymphoid cell neoplasm.