Although the IFNγ/STAT1 signature induced by T cells has recently been reported as a good prognostic factor for ICT response [141], a close control of this cytokine-induced signaling must be maintained since excess IFNγ can induce death of anti-tumor CD8 T cells at a certain stage of their differentiation/activation [142,143,144]. The gene discussed is CD8A; the disease is neoplasm.