Paired CyTOF-based analyses of CD8 TILs and TAM in human renal cell carcinomas [16] showed some correlation between exhausted CD8 TILs, CD4 regulatory T cells and a few peculiar TAM subpopulations (either CD169- CD163- CD68hi CD38hi CD204+; or CD169+ CD163+ CD68hi CD38hi CD204+ CD206+). The gene discussed is SIGLEC1; the disease is hereditary clear cell renal cell carcinoma.