Shotgun proteomic analysis of the CSF from patients with meningitis confirmed the presence of NET-related proteins, such as MPO, NE, proteinase-3 (PR3), cathelicidin LL-37, MMP-9, heparin binding protein (HBP), neutrophil gelatinase-associated lipocalin (NGAL), and histones [66]. The gene discussed is PRTN3; the disease is infectious meningitis.