MiR-195 downregulated SIRT3 expression through direct 3′-UTR targeting in AC16 human cardiomyocyte-like cells, and MiR-195 KO transgenic mice exhibited reduced SIRT3 expression levels associated with hyperacetylation of key metabolic enzymes and energy depletion, leading to cardiac remodeling and heart failure [76]. Here, SIRT3 is linked to heart failure.