Overexpression of c-Myc (Figure 5B,C) or overexpression of AKT (Figure 5D,E) rescued the proliferation inhibition of LNCaP C4-2B cells caused by KDM4C KD, suggesting that KDM4C promotes the proliferation of PCa cells via activation of AKT and c-Myc. Here, KDM4C is linked to posterior cortical atrophy.