Moreover, research looking for new therapeutic targets is still very active in MM, with several novel agents knocking at the door, such as Bcl-2 inhibitors (venetoclax), Exportin-1 (XPO-1) inhibitors (selinexor, recently approved by the FDA), or promising immunotherapeutic approaches including antibody-drug conjugates, bispecific T cell engagers (BiTEs), or CAR-T cells, mainly directed against BCMA and/or other plasma cell-specific antigens [5]. This evidence concerns the gene XPO1 and Miyoshi myopathy.