Alkylators and steroids have remained the backbone for MM treatment for many decades [2] until the beginning of the current century when immunomodulatory drugs (IMiDs) (thalidomide, lenalidomide, and pomalidomide), proteasome inhibitors (PIs) (bortezomib (BTZ), carfilzomib (CFZ), and ixazomib (IXZ)), and anti-CD38 monoclonal antibodies (mAbs) (daratumumab and probably soon isatuximab) were approved and became the backbone of the current standards of therapy both in the USA [3] and Europe [4]. The gene discussed is CD38; the disease is Miyoshi myopathy.