DEK overexpression has been documented in various human malignant tissues, including GC, pancreatic ductal adenocarcinoma, oral squamous cell carcinoma (OSCC), hepatocellular carcinoma (HCC), chronic lymphocytic leukemia (CLL), lung cancer, cervical cancer, breast cancer, melanoma, head-and-neck cancer, bladder cancer, retinoblastoma, T-cell large granular lymphocytic leukemia, colon cancer, prostate cancer, acute myeloid leukemia (AML), and malignant glioma melanoma [8,9,10,11,12,13,14,15,16,17,18,19,20,21]. The gene discussed is DEK; the disease is hepatocellular carcinoma.