In patients with MEN1, Carney Complex, and McCune Albright Syndrome there may be evidence of somatotroph/mammosomatotroph hyperplasia with associated pituitary tumor, thus the presence of coexisting hyperplasia and a distinct tumor in a young patient with acromegaly or gigantism should raise the suspicion of a possible familial disease [55]. The gene discussed is MEN1; the disease is acromegaly.