In contrast, excess production of the GH-releasing hormone (GHRH) is an unusual but well documented cause of acromegaly, and may be associated with neuroendocrine tumors of lung, pancreas, thyroid (medullary thyroid cancer) or pheochromocytomas [2,3], as well as hypothalamic gangliocytomas [4,5]. The gene discussed is GHRH; the disease is acromegaly.