GHRH and neuroendocrine neoplasm: Garby et al. reported that of 20 tumors responsible for the ectopic secretion of GHRH, 12 cases (60%) were pancreatic neuroendocrine tumors, and most of them had distant metastases, seven patients (35%) had bronchial neuroendocrine tumors, and one patient (5%) had an appendiceal well-differentiated neuroendocrine tumor [65].