TLR4 and Cognitive impairment: Notably, F. mume, a processed fruit of Prunus mume, improves BCCAo-induced cognitive impairment via the attenuation of the cholinergic system dysfunction and the inhibition of inflammation-related factors, such as gliosis, toll-like receptor-4 (TLR4), P38 mitogen-activated protein kinases (MAPK), and nuclear factor-κB (NF-κB) [15,18,19].