NADPH oxidase 2 (Nox2)-derived ROS was also reported to induce cancer progression and migration, modulated through the ERK/PI3K/AKT/Src (Proto-oncogene tyrosine -protein kinase)-dependent pathway leading to the activation of endothelial cells and induction of angiogenesis [77,78,79]. The gene discussed is CYBB; the disease is cancer.