Moreover, copper was reported to increase the ROS-mediated expression of VEGF, HiF-1α, and G-protein estrogen receptor (GPER) in HepG2 hepatocellular carcinoma cells and SkBr3 breast cancer cells via activation of the EGFR/ERK/c-Fos pathway [83,84]. Here, HIF1A is linked to breast carcinoma.