CASP8 and Huntington disease: On the other hand, in HD-pathway, proteins that are involved in antioxidant defense system (for example, SOD1 and GPX1), neuronal growth and survival (for example, BDNF), inflammation (for example, COX2), and apoptosis (for example, BAX, CASP3, CASP9, CASP8, and CYCS) were the targets of fucosterol (Figure 7C).