The enhanced efficacy of the vaccine is due to the remodeling of the tumor microenvironment, in which CDDO-Me, delivered by nanoparticle to the tumor mass, remodels the tumor-associated fibroblasts, collagen and vessel and enhances the Fas signaling pathway, which in turn sensitizes cancer cells for killing by cytotoxic T lymphocytes. This evidence concerns the gene FAS and neoplasm.