Furthermore, melatonin and trichostatin A (a histone deacetylase (HDAC) inhibitor) have similar protective effects on neonatal dexamethasone-induced programmed hypertension [84], suggesting that melatonin might act like a HDAC inhibitor to epigenetically regulated hypertension-related genes to prevent programmed hypertension. This evidence concerns the gene HDAC9 and hypertensive disorder.