Vinchi et al. showed, in an in vitro model of endothelial cells (HUVEC) exposed to hematin as well as in two mouse models of β-thalassemia and SCD, that the addition of hemopexin was associated with a decrease in endothelial expression of adhesion molecules (VCAM-1, ICAM-1, E-selectin), a decrease in ROS production, and an increase in NO bioavailability [29]. Here, HPX is linked to Schnyder corneal dystrophy.