The fact that CRC patients harboring the KRAS mutation in their neoplastic tissues have detrimental effect upon administration of monoclonal antibodies like cetuximab and panitumumab, which has otherwise improved the median survival of KRAS wild type patients, has prompted the necessity to precisely understand the molecular events caused by KRAS mutation in the CRC microenvironment. The gene discussed is KRAS; the disease is colorectal carcinoma.