ADH5 and autoimmune disease: For example, the deletion of GSNOR promotes bronchodilation and protection against asthma in the lungs [13], improves post-cardiac arrest resuscitation [14], increases cell senescence in mouse and human models [15], protects against autoimmune disease [16], improves skeletal muscle resistance and fatigue resistance [17], and increases cardiomyocyte proliferation [18] and neuronal differentiation [19].