Both LIN28B and LIN28A from the LIN28 protein family function as the RNA‐binding protein in the cells.14 Highly expressed LIN28 is firstly revealed in liver cancer tissues.15 In addition to liver cancer, LIN28B has also been found to be elevated in neuroblastoma, lung cancer, pancreatic cancer, and colorectal cancer.16, 17, 18, 19 Yet, the association of LIN28B with miR‐563 in any type of cancer remains unexplored. This evidence concerns the gene LIN28B and liver cancer.