Immunoblotting analysis confirmed that two different siRNAs targeting LIN28B mRNA (si‐LIN28B‐1 and si‐LIN28B‐2) could both effectively induce knockdown of LIN28B in lung cancer cells, and the interference effect of si‐LIN28B‐2 was more obvious than that of si‐LIN28B‐1 (Fig 3a). The gene discussed is LIN28B; the disease is lung carcinoma.