Because CT scan showed metastases with stable disease (Fig. 4) and the serum tumor marker (CEA, CA 724, CA 199) levels had no markedly elevated (Fig. 5) 7 years after multidisciplinary treatment, the patient still refuses to detect HER-2 gene expression examined, so we have not combined chemotherapy with targeted therapies. The gene discussed is CEACAM5; the disease is neoplasm.