Patient # 8 presented with asymptomatic optic atrophy (correctable vision loss) and was identified to have a pathogenic variant (WFS1 c.1941C>A; p.Cys647) [38,39] and a VUS (c.1597C>T; p.Pro533Ser) in trans (Table 1) [40]. The gene discussed is WFS1; the disease is Leber hereditary optic neuropathy.