The 738 cases of NSCLC samples with complete clinical information from TCGA database were divided into two groups to was analyzed the relationship between HHIP expression and clinicopathologic features such as age, gender, metastasis of blood vessel and lymph and clinical stage (TNM), etc. 738 cases of samples were divided into HHIP high expression group and HHIP low expression group based on the median. The gene discussed is HHIP; the disease is non-small cell lung carcinoma.