For example, the low expression of HHIP in stromal cells promotes the proliferation of leukemia cells; overexpression HHIP attenuates the activation of HGF/MET and HH pathways, and significantly inhibits lung adenocarcinoma cell proliferation, colony formation, invasion and sphere formation under the condition of serum starvation[8]. Here, HHIP is linked to lung adenocarcinoma.